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5 GLP-1 and various organs GLP-1 has been shown to carry out numerous protective and regulatory functions in different organ systems
The combined activation of GIPR and GLP-1R by tirzepatide not only improved both glucose-dependent insulin secretion and glucose tolerance in mice 38 , but also showed significantly better efficacy than semaglutide and dulaglutide with regard to glucose control and weight loss 15,16
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