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Subcutaneous injection was chosen as 5A-1MQ specifically has poor oral bioavailability in mice, a phenomenon that does not occur in rats 26
Below is a scientific explanation of the mechanisms explored in published studies: 1
Most individuals transition to a maintenance schedule of one injection every 1-3 months, depending on their specific needs and how well they maintain B12 levels through diet and oral supplements
Pair dosing with serial pharmacodynamics (ERR target genes, energetics) and, where feasible, exposure measurements (plasma/tissue)
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