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Metabolite concentrations were normalized to the concentration of water calculated from unsuppressed water spectra, since variations in water content within the sample are expected to be much smaller than the variations in the metabolite level [52]

Senescent cells secrete a toxic mix of inflammatory cytokines, proteases, and growth factors called the Senescence-Associated Secretory Phenotype (SASP)

IGF-1 is a small polypeptide consisting of 70 amino acids that is synthesized and secreted into the bloodstream mainly by the liver and some IGF-1 is acted upon by the kidneys or skeletal muscles in an autocrine or paracrine manner in their own tissues or periphery (7)

Third, rib injuries often lead to compensatory breathing patterns that create secondary muscle tension and pain