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Table of Contents Introduction Tirzepatide is a relatively new medication used to treat type 2 diabetes and aid in weight loss
Interestingly, only a very small amount of GLP-1R is present in the -cell membrane, but GLP-1 can inhibit glucagon secretion in human pancreatic islets by directly acting on GLP-1R on -cells
Reported Efficacy in Published Trial Data Across pivotal trials, mean weight reduction has scaled with receptor coverage in the published readouts [1][9]
doi: 10.1111/j.1365-2265.1995.tb01861.x
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