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Notably, YEATS domain-containing reader proteins release RNA polymerase II from pausing states, enabling efficient transcription elongation-critical for rapid-response genes such as immediate-early genes

High-mobility group box-1 impairs memory in mice through both toll-like receptor 4 and receptor for advanced glycation end products

In sintesi: Per metilazione della lisina si ottiene la 6-N-trimethyllysine (TML) Mediante trimossillisiossigenasi, in presenza di ferro e acido ascorbico (vitamina C), la TML viene idrossilata in idrossitmetililina (HTML) Ad opera della aldolasi, la HTML viene scissa in 4-trimetilamminobutirraldeide (TMABA) + glicina Con l'azione della TMABA deidrogenasi e catalisi di NAD+, la TMABA viene deidrogenata in gamma-butirrobetaina Attraverso l'attivit della gamma butirrobetaina idrossilasi, la gamma-butirrobetaina viene poi idrossilata in L-carnitina, che richiede ferro sotto forma di Fe2+