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Yes, nausea is the most common side effect, affecting 16-44% of patients depending on the formulation

The exact mechanism isn't fully understood, but the additional 5-7% weight loss demonstrates GIP's independent contribution beyond GLP-1 alone

Possible idiopathic intracranial hypertension, which has been reported rarely with GLP-1 agonists

It reversed glucose dysregulation without detrimental effects on metabolically healthy animals and reduced body weight, lowered fasting blood glucose, decreased glycosylated hemoglobin (HbA1C), improved glucose tolerance, and protected pancreatic islet architecture in diabetic fatty Zucker rats 22,23,24