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This mechanism is shared across all GLP-1 drugs, from semaglutide to tirzepatide to retatrutide (PMC12992036)
Cocaine and cocaine expectancy increase growth hormone, ghrelin, GLP-1, IGF-1, adiponectin, and corticosterone while decreasing leptin, insulin, GIP, and prolactin
Extra caution may apply if a patient has: Type 1 diabetes History of pancreatitis Severe stomach emptying problems Gallbladder disease Kidney disease Thyroid cancer history Multiple diabetes medications Pregnancy plans Eating disorder history Very low calorie intake Dehydration or frequent vomiting A safe weight loss plan needs more than a prescription
Mild nausea during the first few days, a brief shift in bowel patterns, or slight abdominal discomfort is common
