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Finally, the cladogram (in addition to Supplementary Table S1) clearly illustrated that the unclassified genera fell within multiple orders/families

Impaired acidification, fusion defects and reduced endosomeautophagosomelysosome pathway flux compromise the clearance of pathogenic aggregates, and raising cellular cAMP or free zinc has been proposed as a strategy to restore lysosomal pH and proteolytic capacity in affected neurons 166

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