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2018;102:e4745
In addition to the rapid epigenetic modulation of glutamatergic function, preclinical studies showed that boosting mitochondrial metabolism of LAC protects against oxidative stress, rapidly ameliorates insulin resistance, and reduces neuroinflammation by decreasing proinflammatory pathways such as NFkB in hippocampal and cortical neurons
LC can improve male reproductive performance and may be its antioxidant effect is the major reason for L-carnitine-mediated tissue protection
Immunotherapy and Combination Approaches Although MPNST is generally considered an immune-cold tumor, 2025 trials are combining PD-1 blockade with MEK inhibitors or radiation therapy to enhance immune activation
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