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[1] [4] According to NICE guidance (NG28), GLP-1 receptor agonists like Trulicity may be considered when specific criteria are met, such as BMI above 35 kg/m (or lower in certain ethnic groups), or when weight loss would benefit obesity-related comorbidities

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This post-translational modification is crucial for establishing repressive chromatin states and silencing developmental genes in a tightly controlled manner during embryogenesis and subsequent tissue-specific development (Hansen et al., 2008)