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Joint and hand symptoms throughout the cycle
h , Relative abundance of cecal metabolites, including short-chain fatty acids (SCFA), branched-chain amino acids (BCAA), tricarboxylic acid intermediates (TCAi), and metabolites involved in creatine synthesis, quantified by nuclear magnetic resonance (NMR)
In principle, sphingomyelin can be hydrolyzed by different enzymes: neutral SMase, acidic SMase, and secreted forms of SMases [120]
Although these trials primarily enrolled individuals with relatively low DKD risk and were not designed to evaluate kidney outcomes specifically, exploratory analyses consistently indicated slower kidney disease progression across diverse eGFR and albuminuria levels [39-44]
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