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The major detoxification pathway of 4HNE involves GSTs 16
Second, GLP-1R activation enhances neurovascular coupling function, improves cerebral blood flow and repairs BBB integrity, blocking the penetration of peripheral inflammatory factors into the center (Wong et al., 2024)
Poor freeze-drying can damage the peptide structure, reducing potency even when the starting material was acceptable
Clinical trials indicate that many patients achieve significant remission or symptom reduction
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