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Nuclear Heme Oxygenase-1 (Ho-1) modulates subcellular distribution and activation of Nrf2, impacting metabolic and anti-oxidant Defenses

Resnick O, Bril F, Beauchamp G

In an average adult, only a small amount (approximately 10% of a therapeutic paracetamol dose) of NAPQI is produced, which is inactivated by conjugation with glutathione

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