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showe that HIF-1 binds to HREs in the promoters of several glycolytic genes, including lactate dehydrogenase A (LDHA), leading to increased gene transcription ( + , ensuring the continuity of glycolysis (71)
The NO synthase blocker L-NAME inhibited up-regulation of angiogenesis markers VEGF-A and CD34 by BPC 157, suggesting that BPC 157 promotes angiogenesis and then further repair the gastric mucosa through NO response
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