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The authors reported that intra-articular AOD-9604 injection in the rabbit osteoarthritis model produced macroscopic, histologic, and biomechanical evidence of cartilage preservation relative to untreated controls, with the combination of AOD-9604 plus hyaluronic acid yielding the most consistent chondroprotective effect [4]
Figure 26: Photograph of Professor Jens Holst with Dr Karen Thorne, a member of his laboratory, carrying out an experiment with a perfused pig pancreas in the 1990s, credit: Holst
enrolled 117 adults undergoing bowel resection and compared intravenous ipamorelin (0.03 mg/kg twice daily for up to seven days) against placebo to assess whether the compound could shorten postoperative ileus [3]
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