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CROT catalyzes the transport of the end product of peroxisomal -oxidation from the peroxisome into the mitochondria (55), thereby indirectly increasing ACOX1 activity and non-mitochondrial respiration by enhancing the flux of peroxisomal -oxidation

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However, studies on CAF supplementation have shown substantial variability in outcomes, with some studies reporting no benefits or even a worsening of performance in certain subjects