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Additionally, semaglutide can make you tired due to its gastrointestinal side effects, including nausea, vomiting, and diarrhea.[1-3] How tired you feel while taking semaglutide is also impacted by how you take semaglutide (pill or injection) and your dosage.[1-3] How You Take Semaglutide Can Affect How Tired You Feel Semaglutide is available as a daily pill (Rybelsus) or a once-weekly injection (Ozempic and Wegovy).[1-3] During clinical trials, individuals taking semaglutide as an injection were more likely to report fatigue (tiredness) as a side effect.[1-3] Patients taking Rybelsus during clinical trials did not report fatigue as a side effect.[2] Those taking 14 mg of Rybelsus did report nausea (20%), abdominal pain (11%), diarrhea (10%), decreased appetite (9%), vomiting (8%), and constipation (5%).[2] During clinical trials for Ozempic and Wegovy (semaglutide injections), patients did report feeling tired.[1,3] 11% of participants taking 2.4 mg of Wegovy for weight management reported feeling tired.[3] Less than .4% of patients reported feeling tired as a side effect during clinical trials for Ozempic.[1] Those taking 1 mg of Ozempic did report nausea (20.3%), vomiting (9.2%), diarrhea (8.8%), abdominal pain (5.7%), and constipation (3.1%).[1] Your Dose Can Affect How Tired You Feel Individuals taking a higher dose of semaglutide are more likely to feel tired.[1-3] Wegovy for weight management offers the maximum dose of semaglutide (2.4 mg) and is associated with a higher incidence of fatigue and other side effects.[1-3] Individuals taking 2.4 mg of Wegovy reported nausea (44%), diarrhea (30%), vomiting (24%), constipation (24%), abdominal pain (20%), and abdominal distension (bloating)(7%) as side effects.[3] Wegovy is available as a pre-filled, single-dose injection pen containing 0.25 mg, 0.5 mg, 1 mg, 1.7 mg, or 2.4 mg of semaglutide.[3] Clinical experience suggests starting on a low dose of semaglutide and slowly increasing the dosage may reduce the risk of side effects.[4] Patients can start with 0.25 mg and increase their dose every four weeks until they reach the maintenance dose (2.4 mg).[3] Consult your healthcare provider if you experience fatigue or other side effects while taking semaglutide

Where fat is lost first varies by individual, but many people notice changes in abdominal fat over time.

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