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The absence of evidence is not the same as evidence of safety, particularly given that ashwagandha is a botanical supplement with variable composition and limited pharmacokinetic data
Phentermine-Topiramate (Qsymia) Combination Appetite Suppression Medication How Its Taken : Oral capsule taken once daily in the morning
Even though lower doses are presumably safer, using them would still require a new pre-IND safety justification, dose-range toxicology studies, and possibly a new manufacturing lot release. That would add ~12 years of delay
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