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In animals, GLP-1R engagement was demonstrated through glucose-tolerance, food-intake, and gastric-emptying readouts, while GCGR engagement was tracked through liver nicotinamide N-methyltransferase (NNMT) messenger-RNA expression and circulating biomarkers including amino acids and fibroblast growth factor-21 (FGF-21)

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Ketogenic and antiketogenic effects of L-carnitine in hemodialysis research subjects [PMID: 2636668] Laboratory literature summary: Ketogenic and antiketogenic effects of L-carnitine in hemodialysis research subjects