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Both modifications sit in the region that IGF binding proteins recognise, and the functional consequence is a large loss of IGFBP affinity while type 1 IGF receptor binding is largely preserved
Melatonin action in neonatal gonadotrophs [PMID: 15119946] Laboratory literature summary: Melatonin action in neonatal gonadotrophs
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Ghrelin receptor antagonists and vaccines have shown promise with reduced food intake and body weight in pre-clinical studies [90, 91]
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