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Saxenda is contraindicated in patients with a family history of medullary thyroid cancer (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

Peripherally, GLP-1R enhances glucose control by increasing insulin secretion and reducing glucagon production, delays gastric emptying and regulates intestinal hormones

Third, insufficient information on medication histories and confounding by indication limits differentiation between drug effects and underlying disease progression and complications