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Each blot was incubated with primary antibodies against phosphorylated p65 (Cell Signaling Technology, 3033, USA), p65 (Cell Signaling Technology, 8242), NLRP3 (Cell Signaling Technology, 15101), -actin (Cell Signaling Technology, 3700), optic atrophy 1 (OPA1, Cell Signaling Technology, 80471), mitofusions 2 (MFN2, Cell Signaling Technology, 9482), dynamin-related protein 1 (DRP1, Cell Signaling Technology, 8570), and Fission1 (FIS1, Zenbio, 505821, China) overnight at 4C

As an essential nutrient, choline is required by the liver to produce phosphatidylcholine, a key component of VLDL particles that export fat from the liver

As shown in Supplementary Figure 1, we did not observe a significant difference in the cell number between the control and ABT263 treatment group

L-Carnitine is a naturally occurring amino acid derivative that is crucial in energy production