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Hydration matters here too

At the same time, portal hypertension, intestinal edema, delayed transit, reduced bile flow, and impaired hepatic clearance further aggravate this imbalance, creating a self-reinforcing cycle between gut ecological disruption and worsening liver function [277, 309]

The ones locate in mitochondria have both GSH-transferase and peroxidase activity ( Also, GSH facilitates the transport and excretion of toxins, through the formation of S-conjugates of activated intermediates, which are water soluble and undergo renal excretion

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