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DOI: Kayal M, Lambin T, Plietz M, et al
Activating mutations of phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) gene confer sensitivity to PD-L1 checkpoint inhibition in metastatic adenocarcinoma patients
Diarrhea: Affecting the overall digestion process, low cobalamin in the diet will result in gastrointestinal disorders
This subjective improvement could reflect placebo effect, improved overall nutritional status from paying more attention to diet, natural adaptation to the medication over time, or actual b12 repletion if deficiency existed
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