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Studies have shown that when NNMTi is combined with a lowcalorie diet, the rate of body weight loss in obese mice is significantly faster than in either singleintervention group, with more pronounced reduction of adipose tissue and greater improvement in insulin sensitivity and hepatic metabolism

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High-dose methionine supplementation has theoretical concerns regarding homocysteine elevation, though this is unlikely at typical lipotropic injection doses

This chain of events fails to occur in the corticosteroids animals after initial inflammation inhibition (Sikiric et al., 2003)