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Dysfunction in GLP-1R signaling has been implicated in multiple pathologies, including type 2 diabetes mellitus (T2DM), obesity, atherosclerosis, Parkinsons disease (PD), Alzheimers disease (AD), non-alcoholic steatohepatitis (NASH), and several cancers

Notably, ILC2 proportions were comparable between IL-33 alone and IL-33 plus melatonin and Luzindole groups ( Figures 2K, L ), yet BALF concentrations of IL-5 ( Figures 2M ) and IL-13 ( Figures 2N ) remained significantly reduced with melatonin treatment, again indicating dampened ILC2 activity rather than altered ILC2 abundance

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