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Symptoms requiring healthcare provider contact include: Rash or erythema spreading beyond the injection site or appearing at distant body locations Persistent or worsening symptoms lasting more than 4 to 5 days Significant pain that interferes with movement or daily function Development of pustules, blisters, or skin breakdown Warmth, increasing redness, or red streaking extending from the injection site (potential cellulitis) Fever, chills, or systemic symptoms accompanying local reactions Recurrent severe reactions at multiple injection sites Signs of possible allergic reaction, including hives, facial swelling, or difficulty breathing Call 911 or seek emergency care immediately for signs of severe allergic reaction such as difficulty breathing, throat tightness, severe dizziness, or widespread hives