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This was the first major setback, suggesting preclinical results might not translate to human disease

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To identify AS-related genes, the keywords atherosclerosis and atherosclerotic plaque were used to query four databases: GeneCards ( Online Mendelian Inheritance in Man (OMIM, Therapeutic Target Database (TTD), and Pharmacogenetics and Pharmacogenomics Knowledge Base (PharmGKB, The target genes from these four databases were normalized and imported into the UniProt database to retrieve UniProt IDs, which were consolidated and filtered to remove duplicates, to acquire the AS-related gene dataset