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Initially developed for type 2 diabetes, GLP-1RAs have demonstrated robust weight loss in randomized controlled trials and real-world settings, leading to their repositioning as cornerstone obesity treatments ( Human metabolic studies consistently show that reductions in energy intake account for most of the weight loss observed during GLP-1RA therapy, whereas increases in resting energy expenditure are modest or absent ( Beyond total weight loss, the quality of weight loss has become an increasingly important clinical concern

"GLP-1 receptor agonists in the treatment of type 2 diabetes - state-of-the-art." Molecular Metabolism, vol

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Holst, J