263 Individuals who are HLA-DQ2 or HLA-DQ8 positive (at risk for celiac disease but not diagnosed with the condition) have also been shown to have altered bowel movement frequency and increased intestinal permeability with gluten consumption and may want to avoid gluten
Patients should contact their GP or healthcare provider if they experience: Severe or persistent diarrhoea lasting more than 48 hours, particularly if accompanied by signs of dehydration (dizziness, reduced urination, dry mouth, confusion) Blood in stools or black, tarry stools, which may indicate gastrointestinal bleeding Severe abdominal pain , especially if constant or worsening, which could suggest pancreatitisa serious adverse effect that has been reported with GLP-1-based therapies
Similarly, T-helper cell 17 skewing condition (TGF-, IL-23, IL-6, IL-1, and IL-21) also results in increased DPP-4 expression [34]
If you are using oral hormonal contraceptives, add a non-oral contraceptive method or a barrier method of contraception for 4 weeks after starting medication and for 4 weeks after each dose increase