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Chronic stress also plays a role here, disrupting sleep, eating patterns, and metabolic health in ways that medication alone doesn't touch
The beneficial effect of TZT in T2DM and obesity is related to the direct activation of GIP and GLP-1 receptors with subsequent improvement of insulin sensitivity and reduction of bodyweight
Others struggle with nausea, vomiting, or stomach discomfort that makes the treatment hard to continue
Husain M, Birkenfeld AL, Donsmark M, for the PIONEER 6 Investigators, et al
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