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GLP-1-derived nonapeptide GLP-1(28-36) amide inhibits weight gain and attenuates diabetes and hepatic steatosis in diet-induced obese mice
Strategies to mitigate this include gradual dose tapering rather than abrupt cessation, concurrent development of sustainable dietary and exercise habits, and potentially transitioning to lower maintenance doses rather than complete withdrawal
Finally, the overwhelming reliance on ectopic subcutaneous models in current research fails to recapitulate the authentic bone microenvironment
Side effects are generally mild and may include temporary redness or swelling at the injection site, nausea, or mild headaches
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