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The PRAC said it will now review all available data on NAION with semaglutide, including data from clinical trials, post-marketing surveillance, studies on the mechanism of action and medical literature (including the results of the observational studies)
Mechanistic evidence has indicated that GLP-1RAs promote bone marrow-derived macrophage polarization into the M2 phenotype via the cAMP-PKA-signal transducers and activators of the transcription 3 (STAT3) pathway [137, 138]
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