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[15] [13] Other notable adverse effects include: Hypoglycemia : Low risk when used as monotherapy, but increased when combined with insulin or sulfonylureas Injection site reactions : Erythema, pruritus, or discomfort in approximately 2% to 4% of patients Fatigue and dizziness : Reported in 5% to 8% of participants Increased heart rate : Mean increases of 2 to 4 beats per minute observed [1] [2] Serious adverse events were uncommon but included acute pancreatitis (approximately 0.2% incidence), gallbladder disease including cholecystitis and cholelithiasis (0.6% in diabetes trials and up to 2.5% in weight management trials, associated with rapid weight loss), and acute kidney injury, typically in the context of severe dehydration from gastrointestinal symptoms

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Topical and Injectable GHK-Cu Routes Compared Topical GHK-Cu has published cosmetic, wound, and trial-context evidence, while injectable GHK-Cu lacks an FDA-approved dosing label and is specifically discussed by FDA in relation to compounded injectable safety concerns [2], [3], [7], [8]