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Interestingly, CD4 expressed by CD4 + T cells or the ectodomain of CD4 (soluble CD4, sCD4) binds the 2 domain of MHC-II to initiate reverse signaling that disrupts MHC II-TLR4 raft domains
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Studies which make use of phosphocreatinine/creatinine for this purpose may suffer from methodological error given the reported negative association between creatinine levels and depression scores (Faulkner et al
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