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This guidance advised that companies should show that the risk of cardiovascular events in T2DM patients didnt increase with the use of their new antidiabetic therapies (drugs or therapeutic biologics), a proactive response to concerns about the cardiovascular safety of some diabetes medications developed previously ( accessed August 25, 2025)

It remains a leading cause of mortality and morbidity in intensive care units (ICUs) worldwide (Yao et al., 2020)