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[8] [29] Traditionally, only noble kavas have been used for regular consumption, due to their more favourable composition of kavalactones and other compounds that produce more pleasant effects and have lower potential for causing negative side effects, such as nausea, or "kava hangover"

Studies have shown that certain types of nerve cellsin the brains of individuals with ASD, such as astrocytes, microglia, and Purkinje cells, exhibit abnormalities in morphology and number

They also may contain unlisted or dangerous ingredients, such as solvents, heavy metals, glass, plastic, fibers, bacteria, fungi or endotoxins

Cell 147(4):742758