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This direct delivery is why the timeline for injections is often measured in days rather than weeks, especially for someone who was deficient

Rat data cannot establish the best timing for either route in people

If a pregnant patient has a documented deficiency of one or more B vitamins or a condition like hyperemesis that prevents oral intake, the benefits of correcting the deficiency (preventing serious maternal and fetal complications) outweigh any minimal risk from the injection

Patients should be advised to report new or worsening neurological symptoms promptly, as these may indicate progressive deficiency requiring more aggressive intervention