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Systemic inflammation and insulin sensitivity in obese IFN- knockout mice
published in Frontiers in Physiology confirmed that BPC-157 dose- and time-dependently increased GHR expression in isolated rat Achilles tendon fibroblasts at both mRNA and protein level, and that GH added to BPC-157-treated fibroblasts produced significant, dose-dependent increases in cell proliferation establishing GHR upregulation as a specific molecular mechanism through which BPC-157 enhances local tissue sensitivity to growth hormone signalling
Studies have highlighted its role in promoting angiogenesis (new blood vessel formation), accelerating tendon and ligament healing, and supporting gastrointestinal integrity with additional research pointing to cytoprotective and anti-inflammatory properties across a broad range of injury models
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