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Pros: One-time treatment Long-term weight loss supported by decades of research Often improves diabetes, blood pressure, and sleep apnea No lifelong medication costs Cons: Requires surgery and recovery Lifestyle changes are necessary For many patients with severe obesity, bariatric surgery remains the most effective long-term treatment available

For the majority of people, 8mg will be the sweet spot where results are excellent and the protocol feels sustainable long term

No dose adjustment is expected for renal impairment based on the pharmacokinetic profile observed in the phase 2 trial

How much weight loss is required for cardiovascular benefits