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Funding Open access funding provided by the Scientific and Technological Research Council of Trkiye (TBTAK)

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Curcumin, apigenin, quercetin, and resveratrol are the most important polyphenols with reported information on their mechanisms of action and clinical trials

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Kidneys were collected, fixed in 10% neutral buffered formalin (24 h) for histopathological examination or were homogenized in ice-cold Tris-HCl (10 mM, pH 7.4) for biochemical assays

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Regular alcohol consumption during long-term nitrofurantoin prophylaxis compounds this risk by adding alcohols direct hepatic burden

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