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As clinical data for both anti-PCSK9 antibodies and GLP-1 analogue molecules are widely available, we used PK-PD modelling to determine the appropriate potency at human GLP-1R for the fusion molecule that should deliver robust glucose control without inducing non-manageable GLP-1 driven adverse events at exposure levels able to efficiently neutralize PCSK9

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Unlike the injectables, which enter the bloodstream directly, the pills are broken down in the stomach, which means the oral doses have to be much, much higher than the Wegovy injections, which cap at 2.4 mg, McCoy explains

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