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In a recent retrospective study based on a nationwide multicenter database of electronic health records of 113 million United States patients, GLP-1RAs, compared with insulin, were associated with a significant risk reduction in 10 of 13 obesity-associated cancers, including pancreatic and colorectal cancer

This can be particularly beneficial when combined with tirzepatide's appetite-suppressing effects, as it may help patients feel satisfied with smaller portions whilst still meeting their nutritional needs

It would therefore be interesting to determine if the opposite approach, i.e., simultaneously inhibiting ARC AgRP/NPY neurons and activating ARC POMC neurons, additively reduces food intake and leads to weight loss in the chronic setting as this would be therapeutically relevant

By carefully designing Ipamorelin to only stimulate the release of GH, many of these unwanted side effects are avoided