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Why it did so well: The sales of the blockbuster type 2 diabetes drug Trajenta have maintained a stable trend since 2019, following Boehringers acquisition of full rights from Lilly

This reaction occurs more frequently with higher concentration formulations and with medications that have longer local residence times

It was shown that L-theanine (600 g/mL) could induce apoptosis of tumor cells through the mitochondrial pathway in human HepG2 hepatoblastoma cells and HeLa adenocarcinoma cells (71)

While this effect contributes to weight loss and glycemic control by prolonging satiety and moderating glucose excursions, it can also produce gastrointestinal symptoms and affect perioperative care