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Any change from this indicates a problem

Copper is a required cofactor for lysyl oxidase, the enzyme that cross-links collagen and elastin which offers a route by which a copper carrier could affect matrix quality

Nutrient Deficiencies Your body needs specific nutrients to metabolize histamine: Vitamin C acts as a natural antihistamine and supports DAO function Vitamin B6 is required for DAO synthesis and histamine breakdown Magnesium stabilizes mast cells and reduces degranulation Zinc modulates immune function and mast cell activity Ironically, copper deficiency can worsen mast cell reactions, even when injecting the copper peptide GHK-Cu

If youre already prescribing, or considering it, the question is the same: how do you operate compliantly while the legal pathway is still being built