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2 The development of and approval of new antihyperglycemic medications has favored the use of different pharmacological families with remarkable properties for the management of additional comorbidities such as renal disease, cardiovascular disease, and non-alcoholic fatty liver disease, that are highly prevalent in this subset

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Other peptides act on collagen gene expression (GHK-Cu via the MAPK/ERK pathway), tissue repair (BPC-157, TB-500), sleep-wake neurochemistry (DSIP via GABAergic and NMDA systems), and cortisol modulation, each targeting a distinct pathway disrupted during the menopausal transition