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At concentrations lower than those of DON, JHU395 has been found to decrease the growth and increase the apoptosis of high-MYC medulloblastoma cell lines, thereby prolonging the survival of treated animals ( GLS1 is the rate-limiting enzyme responsible for the breakdown of Gln

Especially, glycolysis, HIF-1 signaling, NADH metabolism, and oxidative stress were affected

it is used here only as a general analytical-science reference and does not automatically establish mandatory release specifications for an RUO research reagent

The researchers noted these changes could potentially increase the risk of cardiovascular events