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Escalation means increasing the study dose over time to help researchers assess tolerability
Regarding trial duration, this ranged between 26 weeks and 56 weeks in all trials except for two, making a subgroup analysis based on duration unwarranted
Diabetes Care 43 , 487493 (2020)
However, several clinical considerations may influence selection: Patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) should not use any GLP-1 receptor agonist
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