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As melanocyte activity decreases with each treatment cycle and existing pigmented cells shed through normal turnover, newer, less pigmented skin cells emerge at the surface
Research by Anisimov and colleagues demonstrated that Epithalon markedly inhibited tumor development and reduced the maximum size of breast adenocarcinomas in transgenic mice, while other studies showed delayed metastasis development from spontaneous tumors
doi:10.2174/0929867043455602
Inadequate drug treatment (ie, consisting of just one or two drugs, versus a broader combination) can also promote resistance
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