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Given the short timeframe of the GLP-1 demonstration, it is unlikely that there will be cost offsets from improved health due to increased GLP-1 use for obesity that can be documented
They work gradually, subtly, and variably depending on individual biology
In preclinical models, GIP has been shown to decrease food intake and increase energy expenditure therefore resulting in weight reductions, and when combined with GLP-1 receptor agonism, may result in greater effects on markers of metabolic dysregulation such as body weight, glucose and lipids. Incretin hormones are released whenever food is consumed
This pill comes after years of demand for an oral version of the previously injectable-only treatment, and three months after Novo Nordisk beat Lilly to the punch and launched oral Wegovy, the first FDA-approved oral GLP-1, with a self-pay price also starting at $149 a month through August 31
